Long-term efficacy and safety of once-daily mesalazine granules for the treatment of active ulcerative colitis.

However, the amount of medication taken approached significance (90% versus 76%, P =0.07), and all patients in the OD group reported being either “very satisfied” or “satisfied” with their regimen.

also in 8,237 other papers

For induction of remission studies, investigating complete global or clinical remission found no difference between SASP and 5-ASA; only for endoscopic improvement was there a trend toward the superiority of 5-ASA over SASP, which did not reach statistical significance. 8 , 45 Adverse events of 5-ASA versus SASP Regarding adverse events in the maintenance situation SASP and 5-ASA had similar profiles, with odds ratios of 1.16 (95% CI 0.62–2.16) and 1.31 (95% CI 0.86–1.99), respectively.

also in 111,027 other papers

In the ITT population, clinical remission was achieved by 151/191 patients (79.1%) in the OD group and 143/189 patients (75.7%) in the TID group, demonstrating non-inferiority between the OD and TID group, with a highly significant P -value of 0.0001. 82 Endoscopic remission using the endoscopic index was obtained in 135/191 patients (71%) in the OD group and 132/189 (70%) in the TID group at the end of the study (ITT).

also in 132,142 other papers

OD dosing did not lead to superior efficacy, although three out of four studies showed a trend in this sense.

also in 53,322 other papers