In addition, mice vaccinated with either peptide 2 or peptide 4 VLPs showed a trend toward reduced dermonecrosis (ulcer area) on days 2 and 3 post-infection, although this did not reach statistical significance ( Figure 3C ).
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Development of a mimotope vaccine targeting the Staphylococcus aureus quorum sensing pathway.
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Whereas reductions in ulcer area in mice immunized with either peptide 2- or peptide 4-VLPs alone failed to reach statistical significance, mice immunized with combined peptide 2/4-VLPs had significantly reduced dermonecrosis compared to control vaccinated mice on day three post-infection ( Figure 4A ).