Sera from children with autism induce autistic features which can be rescued with a CNTF small peptide mimetic in rats.

Even though a trend towards reduction in lipid peroxidation was noted in P6 pretreated autism sera treated neurons but it did not reach statistical significance ( Fig. 1E ; P6 1 μM, Bonferroni’s post-hoc test, p >0.05).

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1B ; Student’s t-test, p = 0.0642, marginal significance).

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Autism serum with P6 injected group showed a trend towards earlier development of surface righting compared to autism serum alone group; however, the difference did not reach statistical significance ( Fig. 3B , panel 1; autism serum vs. autism serum+P6, Bonferroni’s post-hoc test, p >0.05, Student’s t -test, p = 0.074).

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Nonetheless, there was a strong trend towards increased grooming time in young rats injected with sera from autistic children compared to the sham group suggesting an increased tendency towards a spontaneous repetitive behavior ( Fig. 5A ; Bonferroni’s post hoc test, p >0.05; Student’s t-test, p = 0.014).

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