The relationship of TP53 R72P polymorphism to disease outcome and TP53 mutation in myelodysplastic syndromes.

There was no significant difference in allele frequency in del(5q) MDS vs non-del(5q) MDS cases ( P =0.91); however, differences between non-del(5q) allele frequency and controls approached significance ( P =0.08), as well as del(5q) cases, compared with controls ( P =0.10).

also in 8,237 other papers

1 , 2 , 32 Although we found no significant difference in response rates by genotype ( P =0.75) (73.5% overall response rate, 71.4% for CC, 77.5% for CG and 69.0% for GG), comparison of response duration by genotype showed a trend for increased duration of transfusion independence with C-allele dosage; however, this did not reach statistical significance ( P =0.51) ( Figure 3 ).

also in 111,027 other papers

Although there was no significant differences in PFS in del(5q) MDS by R72P genotype ( P =0.53) or non-del(5q) MDS ( P =0.61), the CC genotype showed a trend of overall improved PFS than G-allele-containing genotypes in del(5q) MDS, whereas G-allele-containing genotypes were associated with improved PFS and OS in non-del(5q) MDS ( Figure 2 ).

also in 53,322 other papers