Expression of the Kynurenine Pathway in Human Peripheral Blood Mononuclear Cells: Implications for Inflammatory and Neurodegenerative Disease.

Importantly we observed highly significant treatment effects, independent of time-point, between control and treated (500 IU/mL IFN-γ) samples for all three KP enzymes: IDO-1 p<0.0001, KMO p = 0.0023 and QPRT p = 0.0002 (Fig B in S1 File ).

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However, whilst not statistically significant, there was a clear trend for 3-HAA to be elevated in treated cultures at 72 hours ( Fig 4C ).

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Similarly, there was a strong trend for AA levels to be elevated in IFN-γ treated PBMC cultures with progressive increase over time, although this did not reach statistical significance ( Fig 4D ).

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