Methylation of HOXA9 and ISL1 Predicts Patient Outcome in High-Grade Non-Invasive Bladder Cancer.

PLoS One · 2015 · PMC4558003 · PMID 26332997

Europe PMC DOI

hedged sentences

0.0570

closest p · 1.1× alpha

0.0610

boldest claim

The sentences

approaching significancep = 0.057so close (0.05 < p ≤ 0.1)

Paradoxically, the mean level of methylation for HOXA9 was lower in HG compared to their low/intermediate-grade counterparts, again approaching significance (29.3%vs 44.0%, p = 0.057) ( Table 2 ).

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approached significancep = 0.061so close (0.05 < p ≤ 0.1)

This increase approached significance for ISL1 (22.1% vs 36.5%, p = 0.061).

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did not reach statistical significanceno p-value reported

Furthermore, and as previously described[ 9 , 13 ], concurrent methylation in HOXA9 and ISL1 was associated with DSM and reduced overall survival, however, this did not reach statistical significance.

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