A plasma cytokine and angiogenic factor (CAF) analysis for selection of bevacizumab therapy in patients with metastatic colorectal cancer.

The interaction between the CAF signature and the effect of bevacizumab was highly significant (interaction P = 0.001 for PFS; interaction P = 0.011 for OS).

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But the change did not reach statistical significance (3.0 to 8.2 ng/mL, P = 0.15 for ANGPTL4; 0.76 to 0.54 ng/ml, P = 0.07 for VEGF-A 121 ).

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Likewise, patients who had lower HGF or VEGF 121 levels also showed a trend toward improved ORR versus patients with higher levels, though the interaction test did not show enough power ( Table 3 ).

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The forest plots provided a clear trend indicating that the outcomes became poorer as the concentrations of these markers increased, patients with baseline VEGF 121 or HGF concentrations in the lowest quartile obtained the most survival benefit from bevacizumab ( Fig. 4 ).

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