Because the association with the C allele was of marginal significance ( P = 0.05), and because we could not adjust for known breast cancer risk factors, we cannot exclude the possibility that such confounding factors might have led to a type I error.
A similar excess of C allele genotypes was also observed in cases under co-dominant and recessive models, but these did not reach statistical significance.
Results The C allele was found to be more common in case subjects than in control subjects (cases, 0.59; controls, 0.54) corresponding to a nominally significant increase in breast cancer risk to heterozygotes and CC homozygotes (odds ratio 1.51, 95% confidence interval 1.01–2.25) in the dominant inheritance model.