Symptoms of depression and anxiety predict treatment response and long-term physical health outcomes in rheumatoid arthritis: secondary analysis of a randomized controlled trial.

However, we found large and near-significant effect sizes when assessing the relationship between persistence of depression/anxiety over time and SJC.

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The relationships between depression/anxiety and SJC and ESR outcomes did not reach statistical significance, and effect sizes were small.

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This represents a 59.7% (95% CI: −0.42, 1.61) reduction in treatment effect for HAQ in patients with extreme depression/anxiety at baseline, which although reflecting a clinically meaningful reduction in size of effect, may have failed to reach statistical significance due to the small proportion of patients with extreme symptoms at baseline.

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