Mice Abundant in Muricholic Bile Acids Show Resistance to Dietary Induced Steatosis, Weight Gain, and to Impaired Glucose Metabolism.

Also fecal excretion of FFAs was doubled in Cyp8b1 -/- mice on HFD although did not reach statistical significance.

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Fecal excretion of cholesterol was increased and there was a strong trend for doubled fecal excretion of free fatty acids, while excretion of triglycerides was unaltered, indicating dampened lipid absorption.

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In line with this, Cyp8b1 -/- mice on HFD had a doubled fecal excretion of cholesterol and a clear trend for a doubled fecal excretion of FFAs, although the latter did not reach statistical significance.

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