Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network.

Interestingly, the core subset of genes that are both downregulated and acquire de novo H3K27me3 in the AstroEGFR* to PT transition showed a highly significant overlap with the subset of Polycomb targets that are significantly downregulated during cell reprogramming ( Supplementary Fig. 2a ).

also in 132,142 other papers

In the case of neuroblastoma, ZNF423 displayed a clear trend of progressively decreased expression with more advanced tumour stages and lower expression was associated with worst prognosis.

also in 19,460 other papers

Specifically, although AstroEGFR*1, which reached overexpression levels comparable to those in AstroEGFR*2, showed a trend of extended survival that did not reach statistical significance, AstroEGFR*3, despite much stronger Zfp423 overexpression, displayed a shorter survival.

also in 53,322 other papers