Reduced Ets Domain-containing Protein Elk1 Promotes Pulmonary Fibrosis via Increased Integrin αvβ6 Expression.

5 G ), but this did not reach statistical significance.

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In contrast with progesterone, dexamethasone was able to inhibit TGFβ1-induced ITGB6 promoter activity and basal αvβ6 integrin cell surface expression and showed a trend toward reducing TGFβ-induced αvβ6 expression in vitro .

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There was a clear trend toward reduced Itgb6 expression in both the saline and bleomycin groups treated with daily dexamethasone compared with the groups treated with daily PBS ( Fig. 5 G ), but this did not reach statistical significance.

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