Hypnotic drug risks of mortality, infection, depression, and cancer: but lack of benefit.

To find 44 of 46 studies showing a positive risk ratio was very highly significant, P<0.000001.

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In the first of these studies, the benefit of the hypnotic for depression was not significant at week 4 after the investigators removed the rating scale items related to insomnia, whereas the week 8 benefit was nominally significant only at the P=0.04 level not correcting for multiple comparisons.

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Hartz and Ross found a significant association of hypnotic use with melanoma and close-to-significant associations for lung and breast cancers 72 .

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These data also showed increased thyroid follicular adenomas and carcinomas combined, and increased testicular interstitial cell adenomas, but the latter findings did not reach statistical significance 62 .

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