Coronary pressure and flow relationships in humans: phasic analysis of normal and pathological vessels and the implications for stenosis assessment: a report from the Iberian-Dutch-English (IDEAL) collaborators.

In stenoses up to 40 mm long, resting wave-free flow velocity was preserved at 24.1 ± 12.6 cm/s; in stenoses over 40 mm, flow velocity was 19.1 ± 7.9, creating a significant trend ( P = 0.01) although not a significant difference in mean values by ANOVA ( P = 0.62) or T -test ( P = 0.15).

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Hyperaemic flow velocity similarly diminished from 39.4 ± 22.4 to 26.7 ± 18.8 cm/s, demonstrating a strong trend.

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Hyperaemic MVR over the whole cycle was low for all stenosis severities, but showed a trend to increase in the most severe strata of stenosis severity ( P trend = 0.01).

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Microvascular resistance ( Figure 5 , middle panel) measured at rest showed highly significant trends to fall with increasing stenosis severity, during both whole cycle and wave-free period specifically ( P trend < 0.001).

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