Role of Occult and Post-acute Phase Replication in Protective Immunity Induced with a Novel Live Attenuated SIV Vaccine.

PLoS Pathog · 2016 · PMC5176322 · PMID 28002473

Europe PMC DOI

hedged sentences

0.0630

closest p · 1.3× alpha

0.0630

boldest claim

The sentences

failed to reach statistical significancep = 0.063so close (0.05 < p ≤ 0.1)

Five of 6 completely protected macaques, the exception being macaque E65, had elevated T CM and reduced T EM (CD28 - CCR7 - ) at day 130 post-challenge compared with day of challenge but failed to reach statistical significance (p = 0.063 Wilcoxon signed rank sum test).

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a clear trendno p-value reported

Although not reaching statistical significance due to outliers there was a clear trend for reduction in the number of CD8 + T EM with a concomitant increase in T CM .

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did not reach statistical significanceno p-value reported

Differences in median frequencies of maximally polyfunctional CD8 + T cells between the groups did not reach statistical significance (ρ = 0.065; Mann-Whitney rank sum test) due to the outlier E71 ( Fig 6 ).

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