Peripheral Serotonin 1B Receptor Transcription Predicts the Effect of Acute Tryptophan Depletion on Risky Decision-Making.

Int J Neuropsychopharmacol · 2017 · PMC5480594 · PMID 27638901

Europe PMC DOI

hedged sentences

0.0670

closest p · 1.3× alpha

0.1690

boldest claim

The sentences

showed a trendP =.067so close (0.05 < p ≤ 0.1)

Again, there was an expected treatment-by-time interaction (F(1,20)=73.105, P< .001): the plasma ratio increased 17.2% from T0 to T5 following TRP+, which showed a trend towards significance (mean T0=0.156, SD=0.046, mean T5=0.189, SD=.015, t(21)=1.931, P =.067), and significantly decreased 85.1% from T0 to T5 following TRP- (mean T0=0.166, SD=0.054, mean T5=0.025, SD=0.012, t(21)=13.860, P< .001).

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approached significanceP >.169not close (p > 0.1)

No interactions between order, treatment, and either wins or losses approached significance (both P >.169).

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a trend towards significanceno p-value reported

A significance threshold of alpha=0.05 (2-tailed) was adopted for all analyses, while .05< P <.10 was considered a trend towards significance.

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nominally significantno p-value reported

There was no other nominally significant correlation between peripheral 5-HT system mRNA levels and ATD-induced changes in decision-making.

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