Lung function development after preterm birth in relation to severity of Bronchopulmonary dysplasia.

For FVC, the increase was significantly greater for all BPD groups compared to the non-BPD group, with a positive trend with increasing disease severity ( P < 0.01 to P < 0.001, P trend <0.001).

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Comparing between groups, the FEV 1 /FVC decrease over time was overall larger in all BPD groups compared to the non-BPD group (borderline significant, P = 0.059) and in particular comparing severe BPD and non-BPD ( P < 0.05).

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Consequently, a pattern of decreased FEV 1 /FVC development over time was observed, with a significant trend test in relation to BPD severity and thus the largest decrease in the severe BPD group compared to non-BPD.

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Perinatal data of all the participants are presented in Table 1 . Spirometry There was a negative trend for FEV 1 and FEV 1 /FVC measured in adolescence associated with BPD severity ( P trend 0.002 for FEV 1 and 0.001 for FEV 1 /FVC).

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There were no significant differences between groups for TLC or RV (Table 3 ). Impulse oscillometry (IOS) Frequency dependence of resistance (R 5–20 ) showed a trend of increasing resistance values with BPD severity ( P trend 0,029), Table 3 .

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