New insights into the metastatic behavior after breast cancer surgery, according to well-established clinicopathological variables and molecular subtypes.

Non-Luminal, revealed a trend toward association with distant relapse among Non-Luminal profiles, although it did not reach statistical significance.

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The independent class analysis shows a tendency of some biomolecular variants toward exclusive pathological locations, with a clear trend toward preferential homing sites, although this finding was not statistically significant.

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The results of the present investigation were in agreement with the findings of an earlier study, which reported that HER2-positive and basal tumors were associated with a higher tendency toward systemic disease than the remaining subtypes, but this failed to reach statistical significance (OR: 1.625; CL: 0.857–3.083; p: 0.135) [ 33 ].

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