Abstracts of the 21th European Congress on Obesity (ECO2014), May 28-31, 2014, Sofia, Bulgaria.

Results Both groups showed highly significant reduction from baseline to 12 weeks follow-up in most biochemical measurements and BMI (kg/m 2 ) (VHFLC,34.1 ± 2.4 to 30.6 ± 1.9 (p < 0.001); LFHC, 33.6 ± 3.6 to 29.9 ± 3.3 (p < 0.001)), %body-fat (34.0 ± 4.8 to 28.0 ± 5.3 (p < 0.001) and LFHC, 33.3 ± 5.4 to 26,73 ± 6.1(p < 0.001)) and visceral adi

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The offspring of obese mothers showed higher brain values at birth in all regions (+70% vs controls, p < 0.05), with a decreasing trend at 1 and 6 months (–35% vs controls, p < 0.01), and restoration of normal values at 12 months (p < 0.01 vs 6 months; p = ns vs controls).

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The association between breakfast consumption and time spent in vigorous physical activity approached significance (estimate = 0.480; t(4) = 1.942; P = 0.052); associations with moderate-to-vigorous physical activity and sedentary time were non-significant.

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In addition, TFAP2B (rs987237) showed marginally significant association with obesity ( p = 0.056) and LCT (rs4988235) was found associated with abdominal obesity (p = 0.030).

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previous year and approaching significance from year 6 to year 5 at p = 0.0635).

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All adipose depots showed a trend to diminish in WT-treated mice and to maintain or increase in KO-treated.

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