Lower temperatures reduce type I interferon activity and promote alphaviral arthritis.

In addition, survival of CHIKV-infected IRF3/7 -/- mice was also marginally less for mice held at 30°C, although the difference only approached significance (p = 0.071).

also in 7,962 other papers

Quantification of the histology (by Aperio pixel count [ 27 ]) confirmed this difference was highly significant ( Fig 1E ).

also in 127,188 other papers

The majority of the transcription factors identified as more active at 30°C by the IPA USR ( Fig 6A and 6B ) also showed a trend towards increased activity in the ISMARA ( S7A Fig ).

also in 50,778 other papers

Thus in a model where viral tropism results in hind limbs becoming a major site of viral replication and disease, a clearly significant reduction in foot titers and disease was again evident for mice housed at 30°C.

also in 554 other papers