Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice.

Compared with mouse IgG treatment, immunization with monoclonal antibody 43D showed a clear trend ( P = 0.09) to decrease the number of AT8 intensely stained neurons in the contralateral hippocampus, though it did not reach statistical significance (Fig. 4a and b ).

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Consistently, the amyloid plaque load was larger in the AD p-Tau-injected animals than in saline/43D and AD p-Tau/43D mice; 43D treatment showed a trend to decrease the plaque load in the AD p-Tau/43D mice compared with AD p-Tau/IgG mice (Fig. 5c and d ).

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