Because performance of the dox group against pretreatment often approached significance but always failed to reach P < 0.05 after adjustment for multiple comparisons, we were curious whether direct assessment of dox versus dox + Ab9 might support or refute the benefit of combination treatment.
Animals given dox alone showed a trend toward improvement in MWM and RAWM, but post hoc comparisons against pretreatment performance never reached significance.
Pearson testing revealed nominally significant correlations between Aβ concentration and the two spatial navigation tasks (MWM and RAWM) but found no significant relationship between Aβ and FC for either peptide in any extract (Table S1).