Primary biliary cholangitis patients exhibit MRI changes in structure and function of interoceptive brain regions.

PLoS One · 2019 · PMC6368379 · PMID 30735529

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0610

boldest claim

The sentences

near-significantp = 0.053so close (0.05 < p ≤ 0.1)

Pruritus score was found to be a near-significant positive factor for anterior insula ALFF [F(1,28) = 4.08, p = 0.053], suggesting that reduced activity of the anterior insula may be driven by PBC patients who do not experience pruritus.

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a strong trendp = 0.061so close (0.05 < p ≤ 0.1)

ALFF of the thalamus exhibited a strong trend toward a decrease in PBC patients relative to control subjects [F(1,28) = 3.80, p = 0.061], suggesting a potential reduction in the activity level of the thalamus.

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highly significantno p-value reported

However, what the present study does allow us to conclude is that even clinically mild PBC is associated with highly significant alterations in structure and/or function of the thalamus and insula.

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did not reach statistical significanceno p-value reported

PBC patients also exhibited reduced spontaneous activity of the anterior insula, and this was more evident in patients that did not experience pruritus (though it did not reach statistical significance).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.