Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: a large-scale genome-wide cross-trait analysis.

Nominally significant genetic correlation with COPD was found for both RHR (Rg = 0.0722; P = 0.0434) and HBP (Rg = 0.0751; P = 0.0467) (Table 1 ).

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Genetic correlation for COPD and CAD was approximately 10%, but this value did not reach statistical significance; we did not observe significant genetic correlation between COPD and stroke (Table 1 ), or additional blood pressure traits, such as systolic blood pressure, diastolic blood pressure (Additional file 1 : Table S3).

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We found significant positive genome-wide genetic correlation of COPD with RHR or HBP, and a positive correlation between COPD and CAD, although this latter association failed to reach statistical significance.

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