Cross-species alcohol dependence-associated gene networks: Co-analysis of mouse brain gene expression and human genome-wide association data.

Strikingly, PFC Aliceblue and NAc Cadetblue 2 showed a highly significant overlap in their gene content, with 72 overlapping genes ( S2 Table ; p = 2.2 x 10 −16 ).

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Although the ALSPAC-nominal gene overrepresentation was not significant for Aliceblue, it approached significance ( Table 1 ).

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Gray26, was significantly overrepresented with ALSPAC-nominal genes, and Cadetblue2 showed a trend towards overrepresentation with significance before correcting for multiple testing ( Table 1 ).

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Overlap with ALSPAC Genes with an ALSPAC GWAS gene-wise p <0.001 were considered nominally significant, and will be referred to as “ALSPAC-nominal genes”.

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