MSH3 modifies somatic instability and disease severity in Huntington's and myotonic dystrophy type 1.

Brain · 2019 · PMC6598626 · PMID 31216018

Europe PMC DOI

hedged sentences

0.0490

closest p · 1.0× alpha

0.0610

boldest claim

The sentences

nominally significantP = 0.049actually significant

MSH3 expression was not significantly associated with somatic expansion ( P = 0.625), whereas the association of DHFR expression, while nominally significant ( P = 0.049), did not survive correction for the number of phenotypes tested.

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approaching significanceP = 0.061so close (0.05 < p ≤ 0.1)

In DM1, the association between 3a and age at onset showed a consistent effect direction, approaching significance ( P = 0.061).

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showed a trendno p-value reported

In DM1, each 3a allele showed a trend towards reduced somatic expansion and delayed onset but was significantly associated with both measures in meta-analysis of Huntington’s disease and DM1.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.