Although a clear trend in favor of HCQ was visible, the differences in mean retinal fluorescence based on normalized gray value comparisons did not reach statistical significance.
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Enhancement of Adeno-Associated Virus-Mediated Gene Therapy Using Hydroxychloroquine in Murine and Human Tissues.
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The sentences
A similar magnitude of increase in GFP protein expression associated with HCQ was also detected by western blot; however, this did not reach statistical significance due to limited NHP tissue availability (n = 2) ( Figures 3 C and 3D).
Investigation into the subcellular localization of AAV revealed a strong trend toward shifting from the cytosol to the nucleus upon HCQ treatment.