Severity in sustained attention impairment and clozapine-resistant schizophrenia: a retrospective study.

Furthermore, the TRS without CR group included a subgroup of patients who had not yet tried clozapine, who tended to show poorer CPT performances than clozapine responders, though this difference did not reach statistical significance even on the degraded CPT.

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The proportions of attentional deficits (an adjusted z score of ≤ − 2.5) on the degraded CPT also exhibited a significant trend, from 36.3% in the non-TRS group to 62.5% in the TRS without CR group and to 83.3% in the TRS with CR group.

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This may explain our finding that the three groups of patients, i.e., non-TRS, TRS without CR, and TRS with CR, showed a clear trend in both continuous CPT performance scores and binary CPT deficit only on the degraded CPT, whereas on the undegraded CPT, the groups of non-TRS and TRS without CR could not be distinguished with statistical significance.

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