PAI-1 5G/5G genotype is an independent risk of intracranial hemorrhage in post-lysis stroke patients.

Ann Clin Transl Neurol · 2019 · PMC6856768 · PMID 31637872

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highly significantno p-value reported

As compared to admission PAI‐1 activity levels, a highly significant reduction was observed; the median value of PAI‐1 activity was below the lower limit of the reference interval when measured immediately after thrombolysis (PAI‐1 activity on admission: median: 2.34, IQR: 1.46–5.17 U/mL; immediately after thrombolysis: median: 0.94, IQR: 0.73–1.18 U/mL).

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did not reach statistical significanceP = 0.091so close (0.05 < p ≤ 0.1)

a clear trendno p-value reported

Interestingly, the median value of PAI‐1 activity at 24 h post‐lysis showed a clear trend for increase in patients with worse long‐term functional outcomes (mRS 3–6); however, the association did not reach statistical significance in this patient cohort ( P = 0.091).

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showed a trendno p-value reported

Patients with PAI‐1 5G/5G genotype showed a trend toward larger post‐lysis intracerebral hemorrhage volume as compared to PAI‐1 4G carriers (median: 16.82, IQR: 1.46–58.16 cm 3 vs. median: 0.67, IQR: 0.26–13.55 cm 3 , P = 0.09; Fig. 2 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.