Menstrual cycle associated changes in hormone-related gene expression in oestrogen receptor positive breast cancer.

NPJ Breast Cancer · 2019 · PMC6858333 · PMID 31754627

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0700

boldest claim

The sentences

borderline significantp = 0.06so close (0.05 < p ≤ 0.1)

The change in AvProg showed a borderline significant correlation with PGR expression ( r = 0.34, p = 0.06), such that the tumours with higher PGR expression showed a greater change in AvProg.

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showed a trendp = 0.07so close (0.05 < p ≤ 0.1)

a strong trendno p-value reported

The AvProlif showed a trend to increase between W1 and W2 (FC 1.3, p = 0.07) and there was a strong trend for the AvProg to be higher in W3; W2 vs.

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did not reach statistical significanceno p-value reported

Thus, the four ERGs comprising the AvERG (a pre-defined composite measure of ERG expression) all increased two to threefold in W2 compared to W1 but this did not reach statistical significance most likely due to the small sample size available.

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