Also, the rows and thickness of INL in the peripheral retina were decreased in the ~22- to 24-month-old/Veh rats compared with the ~5- to 6-month-old/Veh rats, and ~22- to 24- month-old/P021 rats showed a clear trend to rescue the number of rows ( Figures 1C,E,G ).
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Inhibition of AMD-Like Pathology With a Neurotrophic Compound in Aged Rats and 3xTg-AD Mice.
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In the peripheral retina there was a significant decrease in rows and thickness of ONL in WT-21 m/Veh and only in the thickness but not in rows of ONL in 3xTg-AD-21 m/Veh, and P021 treatment showed a trend to rescue these changes ( Figures 3C,E ).
Rows and thickness of INL in the central retina were also decreased in WT-21 m/Veh and 3xTg-21 m/Veh mice, and chronic treatment with P021 prevented these changes in 3xTg-21 m mice; although there was an obvious trend, the rescue of INL thickness by P021 treatment did not reach statistical significance ( Figures 3B,D,F ).