Systemic therapy following craniotomy in patients with a solitary breast cancer brain metastasis.

Breast Cancer Res Treat · 2020 · PMC7031200 · PMID 31953697

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showed a trendno p-value reported

In the multivariate model for OS, ER−/HER2+ subtype (HR 0.24; 95% CI 0.05–1.18; p = 0.08) showed a trend for improved OS.

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failed to reach statistical significanceno p-value reported

We observed some trends that approached but failed to reach statistical significance, possibly because we were underpowered to detect such differences.

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did not reach statistical significanceno p-value reported

When stratifying by type of systemic therapy, hazard ratios did suggest a favorable survival associated with hormonal therapy in ER+ patients (HR 0.54, p = 0.25) or HER2-targeted therapy in HER2+ patients (HR 0.26, p = 0.10), but this did not reach statistical significance.

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