Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver.

At two months, we observed a trend towards downregulation of 45S and Rrn3 expression in CR fed rats, which was marginally significant ( p -value = 0.05) for Rrn3 .

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At two and 10 months of CR, we observed a clear trend to an increase in methylation levels when compared to AL rats for several of the CpG units in the RiboPromoter, 18S and 28S amplicons ( Figure 3 ).

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On the contrary, the CpG sites in the 18S amplicon only showed a trend to age-associated hypermethylation. 3.2.

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Rrn3 expression was highly correlated with 45S expression (also in the outlier sample; Pearson’s correlation coefficient: 0.9, p -value < 0.01; Figure 4 B), and robust linear regression showed a trend towards downregulation with aging, which did not reach statistical significance ( Figure 4 C).

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