Immunological effects of nivolumab immunotherapy in patients with oral cavity squamous cell carcinoma.

Although not quite reaching statistical significance ( p = 0.054), there was a strong trend toward an increase in the proportion of CD8 hi CD3 + T-cells that expressed IFN-γ following nivolumab treatment (Table 2 , Fig. 5 c).

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The CD8 hi CD3 + subpopulation also had a near-significant increase in IFN-γ expression.

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The proportion of these conventional T-cells that had an increase in IFN-γ expression following nivolumab treatment approached significance.

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