Effective control of early Zika virus replication by Dengue immunity is associated to the length of time between the 2 infections but not mediated by antibodies.

By day 30 p.i., neutralizing titers had boosted in the three groups, with DENV-middle convalescent animals showing a slight trend towards higher levels of dilution effective for half-maximum neutralization compared to DENV 3M and naïve groups.

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By days 6 and 7 p.i., there was no viral RNA detection in the DENV-middle convalescent group, while DENV 3M animals showed a trend towards an intermittent viremia and most of the naïve animals still had detectable viral RNA.

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From days 2 to 7 p.i., animals exposed to DENV 12 months before ZIKV infection had a consistently higher expression of IFNγ compared to naïve animals although this difference did not reach statistical significance ( S8B Fig ).

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Moreover, by day 30 p.i., DENV-middle convalescent animals showed a strong trend of having higher levels of anti-DENV IgG compared to the DENV-early convalescent animals, although no statistical significance was reached.

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