Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity.

Nat Commun · 2020 · PMC7305123 · PMID 32561719

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0.0550

closest p · 1.1× alpha

0.0700

boldest claim

The sentences

a strong trendp = 0.055so close (0.05 < p ≤ 0.1)

RT-qPCR confirmed significant reduction of FC-induced RNA increase in Top3β-KO mice for Arc, Egr1 , and Npas4 ( p < 0.05); and a strong trend of reduction for c-fos ( p = 0.055) (Supplementary Fig. 6a-d ).

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showed a trendp = 0.07so close (0.05 < p ≤ 0.1)

In support of this, Pol II signals showed a trend of increase at two of these enhancers ( p = 0.07–0.08) in response to FC (Supplementary Fig. 7a-c ), which are consistent with the earlier findings 16 ; although the Pol II difference between WT and Top3β-KO mice was not significant.

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did not reach statistical significanceno p-value reported

MRI imaging analyses showed that the average percentage of ventricle volume in Top3β-KO mice is increased, but this increase did not reach statistical significance (Supplementary Fig. 3b, c ).

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