Awake prone positioning does not reduce the risk of intubation in COVID-19 treated with high-flow nasal oxygen therapy: a multicenter, adjusted cohort study.

Crit Care · 2020 · PMC7537953 · PMID 33023669

Europe PMC DOI

hedged sentences

0.0550

closest p · 1.1× alpha

0.0550

boldest claim

The sentences

showed a trendp = 0.055so close (0.05 < p ≤ 0.1)

Patients treated with HFNO + awake-PP showed a trend for delay in intubation compared to HFNO alone [median 1 (interquartile range, IQR 1.0–2.5) vs 2 IQR 1.0–3.0] days ( p = 0.055), but awake-PP did not affect 28-day mortality [RR 1.04 (95% CI 0.40–2.72), p = 0.92].

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a strong trendno p-value reported

Our original and adjusted data show that patients in the HFNO + awake-PP group had a strong trend toward a delay in intubation of 2 days; however, 28-day mortality was similar in both treatment groups.

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did not reach statistical significanceno p-value reported

Time from HFNO to intubation was longer in the HFNO + awake-PP in the original (1.0 vs 2.0 days, p = 0.055) and adjusted (2.0 vs 4.1 days, p = 0.054) samples, although differences did not reach statistical significance.

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