Differential transcript usage in the Parkinson's disease brain.

PLoS Genet · 2020 · PMC7660910 · PMID 33137089

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nominally significantno p-value reported

The general trend of statistical significance showed that transcripts which were identified as DTU events by at least one of the methods were likely to be defined at least as nominally significant by the alternative method: 97% of all DRIMSeq DTU events were nominally significant according to DEXSeq and 98% of all DEXSeq DTU events were reported as nominally significant by DRIMSeq.

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did not reach statistical significancep = 0.055so close (0.05 < p ≤ 0.1)

showed a trendno p-value reported

The transcript (ENST00000506244) encoding the full-length protein (SNCA-140), showed a trend for reduced relative expression in PD, but this did not reach statistical significance ( p = 0.055, effect size = −0.48, DRIMSeq).

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highly significantno p-value reported

This suggests that highly significant DTU events identified in our discovery cohort show a similar trend in our replication cohort ( Fig 6B ).

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