A finding of interest in our study is the fact that prehospitalization antibiotic treatment for the acute episode of pneumococcal pneumonia tended to display a protective effect for acute cardiac events, although it did not reach statistical significance in the multivariate analysis.
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Host- and Pathogen-Related Factors for Acute Cardiac Events in Pneumococcal Pneumonia.
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The sentences
A funnel plot analysis ( Figure 1 ) showed a trend toward a higher incidence of acute cardiac complications than expected with serotype 4, whereas serotypes 6A, 5, and 1 had a lower incidence than expected.
Our study, analyzing serotypes isolated from 872 patients and clonal complexes from 742, found a negative trend linking acute cardiac events with some highly clonal serotypes, such as 5 (CC289) or 1 (CC306).