A Mendelian randomization study identified obesity as a causal risk factor of uterine endometrial cancer in Japanese.

While the MR‐Egger analysis result was marginally significant, the BMI effect on UEC in IVW analysis remained significant ( P = .0010) after Bonferroni's correction considering the number of phenotypes and methods ( P < .05/10 = .005).

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BMI effect on UEC was nominally significant with directional concordance with that in Japanese (β = 4.04 × 10 −3 , P = .010 in IVW analysis). 4.

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Although the direction of BMI effect on OC was concordant with that in the previous European studies, 14 , 16 our results failed to reach statistical significance ( P = .12 in IVW analysis).

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1 , 3 , 4 MR‐Egger analysis in European population did not reach statistical significance, possibly due to the conservative nature of the method.

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