5-Fu-Based Doublet Regimen in Patients Receiving Perioperative or Postoperative Chemotherapy for Locally Advanced Gastric Cancer: When to Start and How Long Should the Regimen Last?

Cancer Manag Res · 2021 · PMC7810590 · PMID 33469359

Europe PMC DOI

hedged sentences

0.0090

closest p · 0.2× alpha

0.0940

boldest claim

The sentences

a statistical trendP =0.009actually significant

The number of cycles showed a statistical trend in both groups (OS: P =0.009 in POC, P =0.036 in PEC).

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almost significant tendencyP =0.055so close (0.05 < p ≤ 0.1)

a reliable trendP =0.094so close (0.05 < p ≤ 0.1)

TAC also showed a reliable trend towards increased OS (HR=1.008, 95% CI=0.999–1.018, P =0.094), and an almost significant tendency for PFS (HR=1.009, 95% CI=1.000–1.018, P =0.055).

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approaching significanceP =0.086so close (0.05 < p ≤ 0.1)

However, in the continuous Cox regression model (Model 4), a significant downward association was detected between the cumulative number of cycles and OS risk (HR=0.904, 95% CI=0.836–0.977, P =0.011); this relationship was approaching significance for PFS (HR=0.942, 95% CI=0.880–1.008, P =0.086).

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an increasing trendP =0.094so close (0.05 < p ≤ 0.1)

borderline significanceP =0.094so close (0.05 < p ≤ 0.1)

The number of cycles revealed a statistical significance improving OS rate both in POC (HR=0.904, 95% CI=0.836–0.977, P =0.011) and PEC (HR=0.887, 95% CI=0.798–0.986, P =0.026), while only in POC did the TAC show an increasing trend of risk with borderline significance (OS: HR=1.008, 95% CI=0.999–1.018, P =0.094; PFS: HR=1.009, 95% CI=1.000–1.018, P =0.055).

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of borderline significanceP =0.094so close (0.05 < p ≤ 0.1)

The linear trend observed between the log HR and TAC was of borderline significance ( P =0.094 in OS and P =0.055 in PFS).

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close to being statistically significantno p-value reported

When the variables were dichotomized, both cycles <6 (HR=1.372, 95% CI=0.957–1.967, P =0.085) and TAC >42 days (HR=1.415, 95% CI=0.964–2.077, P =0.076) were close to being statistically significant predictors of OS but not PFS (Model 3).

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marginally significantno p-value reported

Kaplan–Meier curves for OS and PFS are presented in Figure 3 with statistically significant differences and statistical trends between the previously stratified groups evident in OS ( P =0.008 and P trend <0.001 from group A to D) and marginally significant differences and significant trends in PFS ( P =0.050 and P trend =0.006 from group A to D).

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a significant trendno p-value reported

There is a significant trend for higher grade of leucopenia, thrombocytopenia, hepatotoxicity, neurotoxicity, skin reaction, and fatigue in patients who completed the cycles ( P trend <0.05).

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a decreasing trendno p-value reported

An increasing trend in the HR for survival risk was found for TAC in patients with POC, while a decreasing trend was found in the number of cycles among the whole sample of patients.

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