Can Previous Associations of Single Nucleotide Polymorphisms in the <i>TLR2</i>, <i>NOD1</i>, <i>CXCR5</i>, and <i>IL10</i> Genes in the Susceptibility to and Severity of <i>Chlamydia trachomatis</i> Infections Be Confirmed?

Carriage of TLR2 + 2477*A approached significance when assessing CT positive women with a symptomatic course of infection compared to CT positive women without one (OR: 2.6, 95%CI: 0.8–8.0, p = 0.10).

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For women carrying IL10 *G risk of CT infection was slightly lower compared to women who were homozygous wildtype, but this did not reach statistical significance (OR 0.6, 95%CI: 0.3–1.2, p = 0.14).

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Earlier attempts in other complex diseases to use polygenic risk scores, which were based on small numbers of highly significant SNPs identified from GWA studies, achieved only limited predictive value [ 18 ].

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In the original research, using cohort 1, no such near-significant value was found [ 14 ].

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When comparing CT-positive women without symptoms to CT-positive women with symptoms to CT-positive women with TFI, Branković found an increasing trend in carriage of the GG allele ( p -trend: 0.0003).

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