Clinical characteristics and HLA genotypes in Chinese patients with anti-SLA/LP-positive autoimmune hepatitis.

Among the HLA class II alleles, anti-SLA/LP-positive AIH patients showed a clear trend of higher frequency in DRB1*04:01, DRB1*04:05, DRB1*14:01, and DRB1*16:02 alleles compared with healthy patients (8.1% vs . 1.6%, P=0.0089/Pc=0.2139; 21.0% vs . 10.4%, P=0.0201/Pc=0.2139; 3.2% vs . 0.2%, P=0.0334/Pc=0.2139; 12.9% vs . 5.2%, P=0.0411/Pc=0.2139, respectively), and a clear trend of lower frequency in the DRB1*15:01 HLA allele (14.5% vs . 27.4%, P=0.0312/Pc=0.2139) ( Table 4 ).

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Anti-SLA/LP-positive AIH patients with other concomitant autoimmune diseases showed a trend of higher HLA-B*13:01, DRB1*04:05, and DQB1*04:01 allele carrier frequency than those without other autoimmune diseases (18.8 vs . 2.2%, P=0.0490; 43.8% vs . 13%, P=0.0280; 37.5% vs . 8.7%, P=0.0140, respectively) ( Table S3 ).

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However, these associations did not reach statistical significance after Bonferroni’s correction.

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