Ancestry-associated transcriptomic profiles of breast cancer in patients of African, Arab, and European ancestry.

NPJ Breast Cancer · 2021 · PMC7870839 · PMID 33558495

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borderline significanceno p-value reported

3 ), albeit with borderline significance, implying that additional factors beyond pathological stage contribute to the divergent clinical outcome of AA patients with BasalMyo tumors compared to EA patients.

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Compared to AsA patients, ArA patients showed a trend towards lower enrichment scores of the Treg and AMPK signature (Fig. 5a ).

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did not reach statistical significanceno p-value reported

Furthermore, we observed an increase in the proportion of BasalMyo tumors in ArA patients (25.0 vs 16.5% in EA, χ 2 = 1.0E − 4, n.s.), although this did not reach statistical significance as a likely result of the small cohort size.

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reached borderline significanceno p-value reported

In multivariate analysis, AA remained significantly associated with worse survival when adjusted for tumor stage, and reached borderline significance when adjusted for tumor stage and age (Supplementary Fig. 3 ).

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