A Study of Blood Fatty Acids Profile in Hyperlipidemic and Normolipidemic Subjects in Association with Common <i>PNPLA3</i> and <i>ABCB1</i> Polymorphisms.

Nominally significant decreases were also observed, for C20:4n6, C24:1 and C22:6, none of which survived Bonferroni correction, however. 2.2.

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Our findings indicate that (i) the PNPLA3 I148M polymorphism is associated with the total blood FA concentration in a group-dependent fashion, with GG (MM) genotypes displaying clearly higher concentrations compared to the PNPLA3 148C (I) carriers, but only in the hyperlipidemic group, (ii) a strong trend for allele-dosage effect of the ABCB1 G2677T polymorphism is apparent, similarly limited to the hyperlipidemic group, and (iii) significant difference in total blood FA concentration between the two groups is limited to the genotypes that are homozygous for the minor allele of one or the other polymorphism ( PNPLA3 148MM and ABCB1 2677TT, respectively). 2.2.2.

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While a trend of allele dosage effect was apparent, limited—again—in the hyperlipidemic group, it did not reach statistical significance overall nor did it hint at an association with FA saturation as was the case with the PNPLA3 polymorphism.

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