Genome-wide DNA methylation analysis pre- and post-lenalidomide treatment in patients with myelodysplastic syndrome with isolated deletion (5q).

However, there was a trend towards a difference in the number of deaths between the cohorts: the proportion of patients who died in cluster A was 43% (6/14 patients) compared to 19% in cluster B (7/37 patients, p =0.08). Methylation pattern is associated with a trend towards inferior outcome Estimate of overall survival using the Kaplan-Meier method showed a trend towards inferior survival for patients clustering in cluster A.

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In contrast, there was a clear trend towards inferior survival for patients in cluster A.

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The number of patients with mutations in TP53 was higher in cluster A, but this difference did not reach statistical significance.

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