Sleep/wake calcium dynamics, respiratory function, and ROS production in cardiac mitochondria.

J Adv Res · 2021 · PMC8240107 · PMID 34194831

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0600

boldest claim

The sentences

a strong trendp = 0.054so close (0.05 < p ≤ 0.1)

A strong trend of higher OXPHOS‐II-dependent OCR during wake was observed (35.19 ± 6.07 for sleep (n = 26) vs. 59.35 ± 10.3 for wake (n = 29); p = 0.054, Fig. 5 D).

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a clear trendp = 0.06so close (0.05 < p ≤ 0.1)

Our results revealed that cardiac expression of CypD at ZG 0 showed a clear trend towards higher level relative to that at ZG 4 (1.44 ± 0.27 during wake vs. 0.84 ± 0.15 during sleep, p = 0.06; n = 9 and 10 animals; respectively, Fig. 3 B), providing evidence for enhanced sensitivity of opening of mPTP to Ca 2+ during wake period.

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showed a trendno p-value reported

Ironically, MICU1:MCU ratios estimated from mRNA expression levels showed a trend towards higher ratio during sleep.

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a weak trendno p-value reported

When we assessed the amounts of Ca 2+ accumulated in cardiac mitochondria after adding the first 4 pulses of Ca 2+ we observed a weak trend for higher calcium concentrations retained in mitochondria in the sleep group (2.59 ± 0.23 μM.μg −1 protein, sleep group vs. 1.88 ± 0.38 μM.μg −1 protein, wake group, p = 0.10, Fig. 2 C).

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