Cellular and Behavioral Characterization of <i>Pcdh19</i> Mutant Mice: subtle Molecular Changes, Increased Exploratory Behavior and an Impact of Social Environment.

Although KO males also showed a trend toward reduced interaction, with a 14% decrease [M diff = −14.59 s (95% CI, −28.54, 0.18); unbiased Cohen’s d = −0.52 (95% CI, −1.08, 0.00)], this difference is even smaller than for WT MGH males and is unlikely to reflect a real change in behavior (Dunnett’s test, KO vs WT SGH : q (1,72) = 2.07, p = 0.0771).

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Regarding CUX1, the difference was apparent in bin 5 ( Fig. 3 E ).

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This change, combined with another decrease in bin 7 and concomitant increases in bins 2 and 3 that did not reach statistical significance, might indicate a tendency of CR + interneurons to occupy higher positions within the cortex in KO animals.

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