Hsp70 modulates immune response in pancreatic cancer through dendritic cells.

In a more aggressive model of syngeneic pancreatic cancer, orthotopic implantation of PKT cancer cells also resulted in smaller tumors, but the findings did not reach statistical significance (Supplementary figure 1D).

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While WT DCs failed to exert any antitumor effect upon adoptive transfer, Hsp70 −/- DCs were able to show a strong trend toward decreased tumor burden, although it failed to reach statistical significance ( p = .1).

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