Distinct single-component adjuvants steer human DC-mediated T-cell polarization via Toll-like receptor signaling toward a potent antiviral immune response.

Proc Natl Acad Sci U S A · 2021 · PMC8488681 · PMID 34561306

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did not reach statistical significanceno p-value reported

However, as the frequency of donors with the corresponding HLA-II allele is quite low within the population and there is a generally high variation in TT-specific CD4+ T-cell abundance between these donors, the results did not reach statistical significance.

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showed a trendno p-value reported

However, overall MPL-s showed a trend of lower protein levels compared to LPS.

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a clear trendno p-value reported

Nevertheless, we observed a clear trend of expanded antigen-specific CD4+ T cells with MPL-s–stimulated and peptide-pulsed DCs ( SI Appendix , Fig.

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